<![CDATA[遗传多样性的指标]]>genetic diversity(D值)
nucleotide diversity, D, was calculated as the mean pairwise genetic distance of the haplotypes obtained from MEGA X v10.1.8

Shannon entropy (Sn)
S = −pilnpi, where pi is the frequency of each haplotype in the viral quasispecies population

viral evolutionary rates

]]>http://an.forum.genostack.com/topic/624/遗传多样性的指标RSS for NodeSat, 13 Jun 2026 12:35:05 GMTTue, 19 Apr 2022 07:07:50 GMT60<![CDATA[Reply to 遗传多样性的指标 on Tue, 19 Apr 2022 11:27:47 GMT]]>遗传多样性里面有一个很重要的概念 叫作haplotypes reconstruction 单倍型重构 在一个个体中 因为病毒的变异 可能会存在不同的 quasispecies 这些亚种如何用单倍型进行区分 对后续的治疗很有影响

https://sci-hub.st/10.1093/bib/bbs081
9f8b750e-0f25-4c5a-bdc3-f83966ea488d-image.png
图中 淡蓝色和深色是两个不同的单倍型 不同reads 情况就比较复杂

]]>http://an.forum.genostack.com/post/1393http://an.forum.genostack.com/post/1393Tue, 19 Apr 2022 11:27:47 GMT