<?xml version="1.0" encoding="UTF-8"?><rss xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:content="http://purl.org/rss/1.0/modules/content/" xmlns:atom="http://www.w3.org/2005/Atom" version="2.0"><channel><title><![CDATA[NGS数据模拟]]></title><description><![CDATA[<p dir="auto">一，NGSNGS<br />
<a href="https://academic.oup.com/bioinformatics/article/39/1/btad041/6994180?login=false" rel="nofollow ugc">https://academic.oup.com/bioinformatics/article/39/1/btad041/6994180?login=false</a><br />
<a href="https://github.com/RAHenriksen/NGSNGS" rel="nofollow ugc">https://github.com/RAHenriksen/NGSNGS</a><br />
模拟古DNA<br />
现代DNA<br />
单端<br />
双端<br />
输出格式：.fasta, .fastq and Sequence Alignment/Map formats (.bam,.sam,.cram)<br />
支持导入突变  vcf<br />
感觉这个软件特别强调了古DNA和时间  应该是一帮研究古DNA的人搞出来的</p>
<p dir="auto"><a href="https://grenaud.github.io/gargammel/" rel="nofollow ugc">https://grenaud.github.io/gargammel/</a><br />
gargammel也是模拟古DNA的工具 内部调用了ART</p>
<p dir="auto">ART  NIH的一个官方工具  从介绍看只能模拟二代的数据<br />
<a href="https://www.niehs.nih.gov/research/resources/software/biostatistics/art/index.cfm" rel="nofollow ugc">https://www.niehs.nih.gov/research/resources/software/biostatistics/art/index.cfm</a><br />
<a href="http://bioinform.github.io/varsim/" rel="nofollow ugc">http://bioinform.github.io/varsim/</a>   模拟突变</p>
<p dir="auto"><a href="https://www.nature.com/articles/s41437-022-00577-3" rel="nofollow ugc">https://www.nature.com/articles/s41437-022-00577-3</a></p>
<p dir="auto">二代的用art  三代的用 pbsim3</p>
]]></description><link>http://an.forum.genostack.com/topic/974/ngs数据模拟</link><generator>RSS for Node</generator><lastBuildDate>Sat, 13 Jun 2026 12:32:40 GMT</lastBuildDate><atom:link href="http://an.forum.genostack.com/topic/974.rss" rel="self" type="application/rss+xml"/><pubDate>Mon, 24 Jul 2023 03:21:08 GMT</pubDate><ttl>60</ttl></channel></rss>