https://www.nature.com/naturecareers/job/fullstack-developer-european-molecular-biology-laboratory-embl-765829
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Sema4 is a patient-centered health intelligence company dedicated to advancing healthcare through data-driven insights. Sema4 is transforming healthcare by applying AI and machine learning to multidimensional, longitudinal clinical and genomic data to build dynamic models of human health and defining optimal, individualized health trajectories. Centrellis®, our innovative health intelligence platform, is enabling us to generate a more complete understanding of disease and wellness and to provide science-driven solutions to the most pressing medical needs. Sema4 believes that patients should be treated as partners, and that data should be shared for the benefit of all.

We are looking for a talented Scientist- Bioinformatics R&D to join our team. The Bioinformatics Scientist leads translational bioinformatics and product development for NGS pipelines as part of the R&D Bioinformatics department. This scientist is an integral part of an interdisciplinary team that develops computational methods and pipelines to interpret large-scale human genome and transcriptome sequencing data from reproductive health, cancer, and other diseases. As part of a development team of engineers and scientists, this scientist will translate research prototypes into production-quality, scalable pipeline products used by a variety of clinical diagnostics and research projects across many teams at Sema4. This scientist will serve as an authority in these products to other users and teams and optimize them to serve Sema4 data science needs.

RESPONSIBILITIES

Design, develop, and test NGS pipelines for clinical tests and research projects in oncology, reproductive health, and other indications.
Lead or support bioinformatics projects to translate NGS results, as well as public and internal genomic, phenotype, and clinical/EMR datasets, to features and optimizations of clinical utility.
Analyze and integrate heterogeneous NGS data (somatic and germline SNVs, indel variants, copy-number alterations, structural variants, gene fusions, transcript isoforms, RNA abundance, RNA editing and modification) from diverse next-generation sequencing assays (Illumina, Ion Torrent, Pacific Biosciences; targeted panels, whole-exome sequencing, whole-genome sequencing, RNA-Seq; bulk and single-cell) and microarrays.
Work with wet labs and clinical teams to plan and design experiments to generate such data, and analyze this data.
Communicate effectively with collaborators (computational and bioinformatics scientists on R&D and production teams, IT/HPC, clinical lab directors, knowledgebase and curation teams, wet lab staff) to understand and satisfy product and research analysis needs.
QUALIFICATIONS

PhD in Bioinformatics, Biomedical Informatics, Computational Biology, Genomics, or a related discipline requiring strong computational and analytical skills supplemented with biology background
Hands-on experience working with NGS tools with high proficiency, especially for sequence analysis and expression analysis
Strong coding proficiency in R, Python, and SQL programming languages in a Linux environment.
Well-versed in the art of effective communication on interdisciplinary teams (scientists, programmers, and clinicians), especially graphical communication about high-complexity datasets to scientific audiences from different backgrounds.
High self-motivation, great ability to work in both multiple-task and independent fashions.
Good understanding of molecular, cell, and developmental biology, especially where relevant to cancer genomics, oncology, or endocrine neoplasms, and especially molecular cloning and NGS library preparation methodologies.
Developing code using distributed version control tools (especially Git) and software issue tracking/management systems (especially Jira).
Using or developing genome browsers or other tools for visualization of genomic datasets.

Senior Software Engineer
Genospace is looking for a talented team player who wants to solve novel problems and help us build and deliver our software platform. As the leading provider of information technology services in molecular medicine, our software is used today by clinicians and researchers across the country and around the globe to improve patient care.

At Genospace, our mission is to be the leading information platform for applied precision medicine. Our interdisciplinary team is merging the tools and techniques of genomics, healthcare, data analytics, web development, and cloud computing. We serve research, clinical development, pathology, and clinical care customers who work with high-dimensional genomic and other biomedical data. Many of the most advanced precision medicine organizations are powered by Genospace.

Your Impact:

Your work as a Senior Software Engineer at Genospace will impact individuals and organizations across the healthcare landscape: patients searching for the best treatment options, researchers seeking to make advances based on a sea of high-dimensional data, physicians deploying personalized medicine in everyday practice, and laboratories conducting some of the most advanced analyses in the world.

What You’ll Do:

Collaborate with product, design, and data science teams to design, develop, and deliver new product features and enhancements
Provide technical leadership and support throughout the engineering process, from architecture and design to monitoring performance and resolving production issues
Mentor and coach junior and mid-level engineers
Participate in regular peer design and code reviews
Set an example for quality in work, demonstrating, teaching and enforcing engineering best practices in design, development and testing
Foster an engineering culture of continuous improvement, quality, collaboration, humility, and respect
What We’re Looking For:

Capacity to deliver on large, complex tasks with multiple components; investigate and resolve areas of significant ambiguity; identify the work and break down tasks contributing to the team’s objectives over a 2-3 month timespan
Ability to contribute across our stack:
Front End – Vue.js
Back End – Java, Groovy, Grails, Kafka, Micronaut
Data Tier – MongoDB, Elasticsearch
Automated testing – Geb, Selenium
Ability to foresee and test against potential functional and scalability problems and own issues through resolution
Ability to determine accurate and dependable delivery estimates
Ability to identify areas of inefficiency and own the implementation of improvements
A self-starter that uses good judgment in how best to apply their time effectively
Strong commitment to teamwork and a humble attitude
Leadership potential including oversight of junior personnel and the ability to identify areas of improvement and work with individuals to maximize their effectiveness
An interest in making an impact on healthcare and clinical research through technology
Clear and effective communication with technical and non-technical audiences
Education & Background:

Bachelor’s degree in Computer Science, Software Engineering, or equivalent experience
5+ years of professional experience in software development

COVID-19 Considerations:

Genospace is adhering to CDC, State and local orders with regard to COVID-19. The health and safety of our colleagues and their families, as well as potential candidates, is our highest priority.

Due to COVID-19, Genospace has transitioned to a work-from-home model, with working hours based on Eastern Time. Employees are welcome to use our flexible, co-working space, but are not required to come into an office. Please note, this is a remote position.

Genospace is an equal opportunity employer and does not discriminate based on any of the following: race, religious creed, color, age, sex, sexual orientation, gender identity, gender expression or gender characteristics, national origin, religion, marital status, medical condition, physical or mental disability, military service or veteran status, pregnancy, childbirth and related medical conditions, or any other classification protected by federal, state, and local laws and ordinances.