Clinical bioinformatician

[anneng]

Clinical bioinformatician
As part of the diagnostics conducted at the Princess Máxima Center for Pediatric Oncology, whole genome sequencing will be performed in 2024, including implementing pharmacogenetics analysis for all patients. This will be integrated into our genomics platform which is part of a shared diagnostics and research infrastructure developed at the Princess Máxima Center together with bioinformaticians within the research group of Dr. Kemmeren. You will be responsible for developing, validating and performing analyses with the data analysis pipelines generated inhouse, as well as maintaining and developing these pipelines with a focus on pharmacogenetics.

Tasks and responsibilities

You will play a significant role in the data analysis as well as further development, validating, implementation and integration of the genomics platform at the Princess Máxima Center. You will work in close collaboration with bioinformaticians and laboratory specialists, and pharmacists in both the Kemmeren group, the molecular diagnostic laboratory and the Maxima pharmacy.

Specific tasks include:

Validating the Pharmcat tool for analysis of Whole genome sequencing data and embedding the farmacogenetic analysis within the genomics platform
Operational analyses of Whole genome sequencing data.
Further development and implementation of the genomics platform using Molgenis, WDL, Cromwell, REST and large-scale computational infrastructures.
Support data resources used for clinical data analysis.
Setting up and supporting bioinformatic analysis pipelines.
Profile

We expect a highly motivated candidate good communication skills. You are flexible, versatile and a good team player in a dynamic multidisciplinary environment. You are also able manage short deadline (diagnostic) tasks and work in a structured manner with an attention to details.

In addition, you have at least:

A bachelor or master in bioinformatics or similar experience in bioinformatics or data science.
Excellent technical and programming skills are required, preferably in Linux, R, python and java.
Knowledge about next-generation sequencing, genetics, statistics and large-scale computational infrastructures.
Our job offer

We offer a fulltime position (36 hours per week) in a very stimulating and cross-disciplinary clinical and research environment, combining cutting-edge clinical care with state-of-the-art bioinformatics. You will initially be appointed for a period of 1 year with a possible extension. Your gross monthly salary will depend on experience and background, starting in scale 55 with a maximum of €4.842,- gross a month based on a fulltime position (36 hours). You also receive 8,33% gross monthly salary holiday allowance and 8,33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labour agreement ‘cao algemene ziekenhuizen’.

Work environment

You will be part of the translational bioinformatics team at the Princess Máxima Center. This team is responsible for performing and developing bioinformatic data analyses at the interface of clinical care and research. The translational bioinformatics team is at the fore-front of implementing next-generation sequencing technologies in clinical practice including exome sequencing (WES), whole genome sequencing (WGS) and RNA-seq based analyses for all patients. Implementation of novel analysis within existing workflows as well as long-read technologies and other sequencing-based assays are under active development. We have extensive experience with implementing novel technologies in a diagnostic setting and coordinating bioinformatics infrastructures such as High-Performance Computing, workflow management systems and data sharing and collaboration facilities.

The Princess Máxima Center

The Princess Máxima Center for Pediatric Oncology is an integrated hospital and research institute, which integrates healthcare, research and education on pediatric cancer, in a single location in Utrecht. Our institute aims to provide the highest level of care for all children with cancer, with optimal quality of life. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.

Contact

You can apply for this position using the apply button. We invite you to apply as soon as possible, since we will close the vacancy when we have found a suitable candidate. For more information, please contact Dr. Jayne Hehir-Kwa.

Acquisition as a result of this vacancy is not appreciated.

https://werkenbijprinsesmaximacentrum.nl/en/vacancy/clinical-bioinformatician/